Company Profile

Legend Biotech USA

Company Overview

Legend Biotech is a global clinical-stage biopharmaceutical company engaged in the discovery and development of novel cell therapies for oncology and other indications. Our team of over 1,000 employees across the United States, China and Europe, along with our differentiated technology, global development, and manufacturing strategies and expertise, provide us with the strong potential to discover, develop, and manufacture cutting edge cell therapies for patients in need.

Company History

Legend Biotech was founded as an early-stage cell therapy company in 2014. The company was the brainchild of visionary scientists who recognized that antibody-based therapeutics could potentially treat disease and possessed the backgrounds in immunology and gene editing to take the leap.

For two years, Legend Biotech, then known as the “Legend Project,” operated in a room the size of a freight elevator, with the goal of creating a cell therapy for multiple myeloma, a hematological cancer that often relapses and can become refractory. The team produced nanobodies for single-domain antibody drugs and ultimately extended the half-life of the nanobodies with proprietary technologies.

In 2015, Legend’s scientists focused on research for chimeric antigen-receptor T-cells (CAR-T) targeting the BCMA protein, making the biotech one of the first companies in the world to engineer CAR-T cells for the BCMA protein. In 2016, investigator-initiated trials began in China.

In 2017, data from the trials were presented at the American Society for Clinical Oncology (ASCO), which led to a partnership with biopharmaceutical company Janssen Biotech, Inc. to co-develop the anti-BCMA CAR-T, ciltacabtagene autoleucel (cilta-cel). Applications seeking approval of cilta-cel for the treatment of patients with RRMM are currently under regulatory review by several health authorities around the world. CARVYKTI™ (ciltacabtagene autoleucel) was approved by the U.S. Food and Drug Administration in February 2022 and received conditional marketing approval from the European Medicines Agency in May 2022.

Today Legend Biotech is a global, commercial-stage company driven by a passion for patients. We continue to build our pipeline of cell therapy platforms, which includes CAR-T, CAR-NK, CAR-?? T and non-gene-editing CAR technologies.

Our goal is to bring hope and opportunity to patients and their families by continuing to explore unique technologies.

Positions Available
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  • 3 days ago

    Associate Director, Talent Acquisition, Pipeline

    Legend Biotech USA - Somerset, NJ, United States
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    Legend Biotech is seeking Associate Director, Talent Acquisition, Pipeline as part of the Human Resourcesteam based in Somerset, NJ. Role OverviewThe Associate Director, Talent Acquisition, Pipeline will serve as a strategic advisor and thought partner to business and HR leaders across Legend Biotech's Pipeline functions. This leader will be accountable for designing, owning, and executing talent acquisition strategies across critical domains-including R&D, Early Drug Development (EDD), Clinical ...

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  • 6 days ago

    Director, Regulatory CMC

    Legend Biotech USA - Somerset, NJ, United States
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    Legend Biotech is seeking a Director, Regulatory CMCas part of the Regulatory Affairs team based in Somerset, NJ. Key ResponsibilitiesServes as the regulatory CMC representative on core teams, develops and plans regulatory CMC submission strategy for multiple platforms. Provides guidance to technical team members for the requirements, especially on the unique requirements on different platform technologies. Identify the required documentation to support global submissions and coordinate the ...

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  • 14 days ago

    Sr. Director of Toxicology

    Legend Biotech USA - Philadelphia, PA, United States
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    Legend Biotech is seeking Sr. Director of Toxicologyas part of the Clinical Development team based in Philadelphia, PA or Somerset, NJ. Role OverviewWe are seeking a highly experienced and strategic Senior Director of Toxicologyto lead and oversee all nonclinical safety assessment activities for our cell and gene therapy programs. This individual will play a pivotal role in guiding toxicology strategy from early research through IND-enabling studies and into clinical development, ensuring regulatory ...

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  • 15 days ago

    Global Chief Medical Officer

    Legend Biotech USA - Somerset, NJ, United States
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    Legend Biotech is seeking a Global Chief Medical Officer as part of the Clinical Development team based in Somerset, NJ. Role OverviewLegend Biotech is a global, integrated cell therapy company dedicated to discovering, developing, and manufacturing transformative therapies for patients with cancer, autoimmune, and other serious diseases. The company has a vision of harnessing the power of the immune system to create durable and potentially curative treatments. By combining deep scientific ...

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  • 19 days ago

    Talent Acquisition Specialist (Contract)

    Legend Biotech USA - Somerset, NJ, United States
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    Legend Biotech is seeking Talent Acquisition Specialist as part of the Talent Acquisition team based in Somerset, NJ. Role OverviewTalent Acquisition Specialist is responsible for attracting and engaging top talent to deliver positive business outcomes. This individual will execute recruitment strategies partnering with HRBP and Hiring Managers to identify and fill vacancies and proactively pipeline talent. Key ResponsibilitiesManage full-cycle recruitment activities to ensure successful ...

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